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Though Weaver doesn't look to be appearing, most of the cast of Ghostbusters: Afterlife will be back for the yet-to-be-named including Mckenna Grace, Finn Wolfhard, Logan Kim, Celeste O'Connor, Carrie Coon, Paul Rudd, Ernie Hudson, and William Atherton.
Source: https://comicbook.com/movies/news/ghostbusters-star-sigourney-weaver-not-returning-afterlife-sequel/